Protein Details: Inward rectifier potassium channel 4

Protein ID

ICDB_Pro_0545

Protein Name

Inward rectifier potassium channel 4

Gene Name

KCNJ4; IRK3

Organism

Homo sapiens (Human)

Length

445 amino acids

AlphaFoldDB

AF-P48050-F1-model_v4.pdb

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)

Sequence

MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI

PDB Structures

3GJ9

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Prostate Cancer and Andersen Cardiodysrhythmic Periodic Paralysis

Location

Heart; skeletal muscle; and several different brain regions including the hippocampus.

DOI ID

10.1073/pnas.91.13.6240; 10.1016/0014-5793(94)00612-1; 10.1016/s0021-9258(17)32016-1; 10.1186/gb-2004-5-10-r84; 10.1038/990031; 10.1101/gr.2596504; 10.1016/0896-6273(95)90103-5; 10.1073/pnas.102609499; 10.1016/j.jmb.2009.07.060

RefSeq

NP_004972.1; NP_690607.1